R. Ramage, C. Ashton, D. Hopton
1984
Citations
0
Influential Citations
19
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The potential application of 1-oxo-1-chlorophospholane (5) as a novel reagent for the in situ activation of Nα -protected amino acids for use in peptide bond forming reactions has been examined. Wherever possible, 32.4Mhz 31 P nuclear magnetic resonance (n.m.r.) spectroscopy was employed to follow both the formation of the intermediate phospholanic-carboxylic mixed anhydride and the subsequent aminolysis reaction.