A. Myles, P. Bacon, K. A. Williams
Nov 1, 1967
Citations
0
Influential Citations
19
Citations
Quality indicators
Journal
Annals of the Rheumatic Diseases
Abstract
During the past 3 years we have been studying the new anti-inflammatory drug mefenamic acid (N(2,3-xylyl) anthranilic acid) in the treatment of painful musculo-skeletal conditions. Cahill, Hill, Jessop, and Kendall (1965) showed that it was effective in the treatment of osteo-arthritis. The object of this study was to determine whether mefenamic acid was of value in the treatment of rheumatoid arthritis. We made a preliminary assessment of mefenamic acid in comparison with indomethacin, a drug which has been well documented (Hart and Boardman, 1965; Smyth, 1965; Pitkeathly, Banerjee, Harris, and Sharp, 1966) and then compared mefenamic acid with placebo in a double-blind controlled trial.