Qiu Fei
2011
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Journal
Fine Chemical Intermediates
Abstract
1-Benzyl-3-hydroxypyrrolidine-2,5-dione could be synthesized via melting reaction of the salt formed by L-malic acid and benzylamine in methanol.The reaction was carried out at different temperatures and times.We found that the best conditions were 140℃ and 8h with the yield of 68%.The structure of the target product was confirmed by 1H NMR,IR and specific rotation.