N. Kosower, Y. Zipser, E. Kosower
Aug 1, 1980
Citations
1
Influential Citations
6
Citations
Quality indicators
Journal
Archives of biochemistry and biophysics
Abstract
Abstract Brief incubation of human red cells with the membrane mobility agent, 2-(2-methoxy)-ethoxyethyl 8-(2-n-octylcyclopropyl)-octanoate (A2C), produces stomatocytes (with invaginations) along with a decrease in osmotic fragility, an altered distribution in a two-phase dextran-polyethylene glycol-water system, and increased permeability to the GSH oxidant, the diazene derivative, 1,2-diazenedicarboxylic acid bis(N′-methylpiperazide). These changes are consistent with what would be expected for agents which increase membrane lipid disorder. Membrane mobility agents provide a very convenient means for altering membrane properties and should be useful for studies on both normal and abnormal red cells.