M. Jago, J. Edgar, L. W. Smith
Jul 1, 1970
Citations
2
Influential Citations
83
Citations
Quality indicators
Journal
Molecular pharmacology
Abstract
The heliotridine-based pyrrolizidine alkaloids lasiocarpine and heliotrine were metabolized in vitro by rat liver microsomes to one main chloroform-extractable and water-soluble pyrrolic derivative, which was isolated and idenitified as dehydroheliotridine (6,7-dihydro-7α-hydroxy-1-hydroxymethyl-5H-pyrrolizine) by chromatography and nuclear magnetic resonance and mass spectroscopy. Only trace amounts of this metabolite were formed from the N-oxides of lasiocarpine or heliotrine, and it was not formed from supinine.