Z. Naikai, D. Xiuying, X. Xijuan
Jul 1, 2000
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Journal
Bulletin of Environmental Contamination and Toxicology
Abstract
N'-(2,4-dimethylphenyl)-N-methylformamidine is a relatively new pesticide developed in China. The pesticide is similar to amitraz or N'-(2,4-dimet hylphenyl)-N-[(2,4-dimethylphenyl) imino]methyl-N-methylmethanimidamide. The metabolic fate of amitraz has been studied by Knowles (1981,1989). The present study describes the identification of N'- (2,4dimethylphenyl)-N-methylformamidine and its metabolites in rat livers by GC/FTIR and GUMS, and the quantitative analysis of the metabolites in the urine, blood, liver, kidney and spleen by GC-ECD at various times following the oral treatment with N'- (2,4dimethylphenyl)-N-methylformamidine. The absorption, distribution, degradation of the pesticide in rat body and excretion along with urine were discussed.