M. E. Cohen, F. S. Coombs, S. Cobb
Aug 1, 1943
Citations
0
Influential Citations
3
Citations
Journal
Journal of Nervous and Mental Disease
Abstract
Azosulfamide (disodium 4-sulfamidophenyl-2′-azo-7′-acetylamino-1′-hydroxy-naphthalene-3′, 6′-disulfonate) has been demonstrated to exhibit anticonvulsant action in patients with epilepsy. 1 Associated with the anticonvulsant effect, alterations in the concentration of chemical constituents of the serum were described. These included a decrease in the carbon dioxide content of the serum, a decrease in the carbon dioxide—combining power of the serum and an elevation in serum chlorides. 1b The purpose of the present study was to determine in more detail the nature of the metabolic changes associated with ingestion of azosulfamide, as well as with phenobarbital, a drug with well known anticonvulsant properties. PLAN OF STUDY Two patients with epilepsy were selected for this study whose seizures were known to have diminished during administration of azosulfamide (cases 3 and 2 1b ). One patient suffered from many petit mal attacks daily; the other, from severe generalized convulsions. The general plan of the study was as follows: After