W. Sterling, J. Henderson, H. Mandel
Feb 1, 1962
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0
Influential Citations
22
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Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract The distribution, excretion and metabolism of the carcinostatic amino acid derivative, 1-amino cyclo pentane-1-carboxylic acid, was investigated in normal and tumor-bearing mice. After intraperitoneal injection of 14 C-carboxyl-labeled drug, the amount of radioactivity in the blood remained constant for 4 days, while the urinary excretion of this drug also remained at a constant low level during this period of time. An insignificant quantity of 14 CO 2 was liberated. All the tissues and tumors analysed contained significant amounts of radioactivity, almost all of which was in the cold acid-soluble fraction. There was very little incorporation of the drug into protein. Chemical fractionation and chromatography of tissues, tumor cells and urine have indicated that all radioactivity present was in the form of the original compound. The significance of these results is discussed.