K. M. Baker, M. Coerezza, L. Del Corona
Feb 1, 1974
Citations
0
Influential Citations
7
Citations
Journal
Journal of pharmaceutical sciences
Abstract
Abstract 5-Acetamido-1-methyl-2-(2′-pyrimidyl)imidazole is shown to be one metabolite of 1-methyl-5-nitro-2-(2′-pyrimidyl)- imidazole in both rats and humans. Characterization was carried out by mass spectroscopy, NMR, and IR and by synthesis of the metabolite. This first example of a metabolite reduction product of the nitro group of an imidazole is discussed in relation to previous studies.