J. Bakke, J. Rafter, P. Lindeskog
Jul 1, 1981
Citations
0
Influential Citations
20
Citations
Journal
Biochemical pharmacology
Abstract
Abstract In contrast with conventional rats, 2-acetamido-4-(chloromethyl)thiazole was not metabolized to the 4-(methylthiomethyl)-, 4-(methylsulfinylmethyl)- and 4-(methylsulfonylmethyl) analogues by germfree rats. Mechanisms for the formation of these metabolites from the mercapturate and the S-glucuronide are proposed. These mechanisms involve the biliary excretion of a mercapturic acid conjugate and an S-glucuronide conjugate which are metabolized in the intestine to metabolites that are reabsorbed, metabolized and excreted with the urine.