M. Serve, D. Bombick, J. Clemens
Mar 1, 1992
Citations
1
Influential Citations
3
Citations
Quality indicators
Journal
Chemosphere
Abstract
Abstract The urinary metabolites of 2-methylheptane (2-MH) in male Fischer 344 rats, administered the hydrocarbon by gavage, included 2-methyl-1,2-heptanediol, 2-methyl-1,5-heptanediol, 2-methyl-2,5-heptanediol, 2-methylheptanoic acid and 2-methyl-5-hydroxy-1-heptanoic acid. Metabolism strongly favored the formation of diols. The metabolites were identified using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). Histopathologic examination of the kidneys revealed minimal hyaline droplet formation (α2u-globulin nephropathy) in the proximal tubule area.