R. Kammerer, E. Distefano, J. Jonsson
Aug 15, 1981
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Influential Citations
2
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Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract The in vitro metabolism of 2-nitro-1-phenylpropane by rabbit liver microsomes was examined. The metabolites, identified by gas chromatography-mass spectrometry, were benzyl alcohol, benzoic acid, phenylacetone, 1-phenyl-2-propanon-1-ol, and 1-phenyl-1,2-propanediol. The mass spectra of these compounds are discussed in terms of the major diagnostic peaks. the levels of the metabolites formed were determined by quantitative gas chromatography, and the major metabolites were phenylacetone and 1-phenyl-2-propanon-1-ol. the formation of these two compounds appears to be P-450 dependent since the reactions are sensitive to CO and 2,4-dichloro-6-phenylphenolxethylamine (DPEA) and inducible by phenobarbital pretreatment of the rabbits.