J. P. Fernandez, Y. Robbe, J. Chapat
Sep 1, 1983
Citations
0
Influential Citations
4
Citations
Journal
Journal of medicinal chemistry
Abstract
Molecular biotransformation of 2-phenylthiazolidine (1) and its m-bromo derivative (2) in the mouse is followed by autoradiographic studies and assessed by analysis of urinary metabolites. Cysteamine (4) is one of the metabolites of compounds 1 and 2. Radioprotective activity and efficacy over a period of time of 1, 2, and 4 correlate closely with distribution and metabolism.