Eric Eisenstadt, Barry Shpizner, A. Gold
Jun 16, 1981
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Biochemical and biophysical research communications
Abstract
Abstract Liver microsomes and reconstituted cytochrome P-450 systems purified from phenobarbital or 3-methylcholanthrene pre-treated rats metabolize cyclopenta(cd)pyrene at its K-region to trans -9,10-dihydroxy-9,10-dihydrocyclopenta(cd)pyrene. The rate of formation of the K-region product is from 5% to 25% that of trans -3,4-dihydroxy-3,4-dihydro-cyclopenta(cd)pyrene. The preference of microsomes and purified cytochromes P-450 for oxygenating cyclopenta(cd)pyrene at the ethylenic C(3)–C(4) position is explainable in part by the fact that the C(4) position has the greatest electron density in the highest occupied molecular orbital.