A. Beckett, R. T. Coutts, G. Gibson
Sep 1, 1975
Citations
0
Influential Citations
11
Citations
Journal
Journal of Pharmacy and Pharmacology
Abstract
A study of the in vitro metabolism of dibenzylamine with fortified rabbit liver 9000 g supernatant fractions has shown that N‐oxidation is the major metabolic process. Of the total amount of dibenzylamine metabolized, 90% is converted to NN‐dibenzylhydroxylamine. The primary amine, benzylamine, is formed to the extent of only 6% of total substrate metabolized. The identity of the major metabolite, NN‐dibenzylhydroxylamine has been established by thin‐layer chromatography, gas‐liquid chromatography and combined gas‐liquid chromatography‐mass spectrometry.