D. Hutson
1976
Citations
0
Influential Citations
33
Citations
Journal
Food and cosmetics toxicology
Abstract
Abstract The comparative metabolism of [ 14 C]dieldrin has been investigated in control and dieldrinpretreated rats and mice. Metabolites excreted in the urine and faeces, and retained in the livers, kidneys and fat of the five animals in each treatment group were investigated. Pretreated animals received 20 ppm (rats) or 10 ppm (mice) dieldrin in their diet for 28 days prior to the ingestion of [ 14 C]dieldrin. The metabolism of [ 14 C]dieldrin in liver microsomal preparations has also been examined. The major metabolic pathways of dieldrin, leading to 12-hydroxydieldrin, 4,5- trans -dihydroaldrindiol, aldrin-derived dicarboxylic acid and the pentachloroketone are present in both rats and mice. The main differences between the species were a more rapid metabolism of dieldrin in rats, a much greater production of the pentachloroketone by rats, and the production of small amounts of polar urinary metabolites by mice. The two strains of mice were similar to one another in most but not all of the parameters measured. The results are discussed in relation to the increased incidence of liver tumours in CF1 mice exposed to dieldrin.