John R. Barnes, Katherine E. Ranta
Oct 1, 1972
Citations
2
Influential Citations
63
Citations
Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
Abstract N-Methylformamide has been isolated and identified in rat urine as a metabolite of dimethylformamide when the latter is administered to rats sc. N-Methylacetamide and acetamide have been isolated and identified in rat urine following sc doses of dimethylacetamide. In vitro studies with liver homogenates and enhancement of demethylation when N-demethylase was induced by phenobarbital in the liver support demethylation as a metabolic pathway for these substituted amides.