E. Crampton, W. Dickinson, G. Haran
Nov 1, 1978
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
British journal of pharmacology
Abstract
Dothiepin hydrochloride (Prothiaden, 11-(3-dimethyl-aminopropylidene)-6, H-dibenzo(b,e)thiepin hydrochloride) is a tricyclic antidepressant currently used in the treatment of depression. In this study the metabolic fate of ['4C]-dothiepin hydrochloride has been studied after administration of a single oral dose to rat, dog and cat (2 mg/kg), baboon (5 mg/kg) and man (50 mg single dose). Absorption was rapid in all species studied and in the rat it was shown that the major site of absorption of dothiepin was in the small intestine. Elimination of radioactivity from the circu-lation, up to 24 h after a single oral dose of ["4C]-dothiepin hydrochloride was slower in man and the baboon than in the dog, cat or rat. In all species 49.0-61.7% of the dose was recovered in the urine and 14.9-41.0% in the faeces. differences separated chromatography