B. F. Stimmel, J. May, J. Randolph
Apr 1, 1951
Citations
0
Influential Citations
17
Citations
Quality indicators
Journal
The Journal of clinical endocrinology and metabolism
Abstract
IN REVIEWING the literature on ethinyl estradiol, Thompson has pointed out that despite the increasing clinical use of this orally potent estrogen, there is a relative paucity of information on the more subtle details of its fate in the various parts of the body, such as its site of inactivation, degradation products, path of excretion, and effect on the pituitary (1). As part of a study on the metabolism of therapeutic doses of the natural estrogens in man we reported that we were unable to detect colorimetrically, measurable amounts of estradiol, estrone, and estriol in the urine following oral treatment with 1.0 mg. of ethinyl estradiol, where as a somewhat similar dose (2.0 mg.) of α-estradiol yielded measurable amounts of all three of these estrogens in the urine (2, 3). Apparently no other studies of the urinary estrogen excretion products of ethinyl estradiol have been reported. In view of the important implications of such a study with regard not only to the intermediary metabolism of this derivat...