R. Mcmahon, H. Sullivan
Jul 1, 1965
Citations
0
Influential Citations
27
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract The in vivo metabolism of the herbicide diphenamid (N.N-dimethyldiphenyl-acetamide) was studied in rats. The compound appeared to be well absorbed and relatively easily metabolized to excretable metabolites. The main route of metabolism was found to be N-dealkylation to nordiphenamid which in turn was excreted as an N-glucuronide. The most interesting metabolite found in urine was the O-glucuronide of N-methyl-N-hydroxymethyl diphenylacetamide. The N-hydroxymethyl compound, often suggested as an unstable intermediate in the N-demethylation reaction, was in this case stabilized by glucuronide formation and excreted in urine. A minor pathway of metabolism of diphenamid was found to be p-hydroxylation.