P. Sims
1970
Citations
0
Influential Citations
65
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract 7,12-Dimethylbenz[a]anthracene was converted by mouse embryo cells into its 8,9-dihydrodiol and into the 8,9-dihydrodiols of the corresponding hydroxymethyl derivatives. Carboxylic acids, arising from oxidation of the methyl groups were also formed. 7-Methylbenz[a]anthracene was similarly metabolized into the 7-hydroxymethyl derivative, the 8,9-dihydrodiol both of the hydrocarbon and of the 7-hydroxymethyl derivative and benz[a]anthracene-7-carboxylic acid. 7-Bromomethylbenz[a]-anthracene yielded mainly 7-hydroxymethylbenz[a]anthracene, probably by a non-enzymic reaction. The metabolites of benzo[a]pyrene were 3-hydroxybenzo[a]pyrene, 1,2-dihydro-1,2-dihydroxybenzo[a]pyrene and 9,10-dihydro-9,10-dihydroxybenzo[a]pyrene. No ‘K-region’ dihydrodiols were detected with any of the above substrates. Benzofe]-pyrene was converted by embryo cells into a phenol and into the ‘K-region’ dihydrodiol, 4,5-dihydro-4,5-dihydroxybenzo[e]pyrene. The phenol and the dihydrodiol were meta-bolites of the hydrocarbon in rat-liver homogenates. With embryo cells all the hydro-carbons yielded unidentified water soluble metabolites.