J. Gage
1967
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Food and cosmetics toxicology
Abstract
Abstract At least 80% of an oral dose of [14C]menazon (O,O-dimethyl S-(4,6-diamino-s-triazin-2-ylmethyl)phosphorodithioate) to rats appears in the urine within 24 hr. The urine contains no unchanged menazon. The major metabolites in urine are the oxygen analogue of menazon, its desmethyl derivative and 2-methylsulphinylmethyl-4,6-diamino-s-triazine, which must derive from hydrolysis of menazon to give the thiomethyltriazine followed by methylation and oxidation at the sulphur atom to give the sulphoxide. A small proportion of the dose is probably also excreted as 2-methoxymethyl-4,6-diamino-s-triazine. These metabolites represent about 80% of the radioactivity excreted; small amounts of three other basic metabolites were also detected but these have not been identified. A scheme is proposed for the metabolism of menazon in the rat.