A. Beckett, D. M. Morton
Dec 1, 1966
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0
Influential Citations
1
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Journal
Journal of Pharmacy and Pharmacology
Abstract
Isomeric methoxyoxindoles are metabolised by rats, guinea‐pigs and rabbits to phenolic metabolites by O‐demethylation and hydroxylation. This has been shown by comparison of the physical characteristics of the metabolites with those of standard synthetic hydroxyoxindoles. Negligible O‐demethylation of methoxyoxindoles occurs with rat or guinea‐pig liver microsome preparations, when compared with those of rabbit, but significant O‐demethylation occurs with rat liver slices.