V. Wacher, J. Casida
Feb 1, 1993
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Influential Citations
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Journal
Journal of Agricultural and Food Chemistry
Abstract
cis- and trans-2-(4-bromophenyl)-5-tert-butyl-1,3-dithianes and 11 of their S-oxidation product undergo NADPH-dependent oxidation by cytochrome P-450 in mouse liver microsomes. The cis comers (2-aryl group arial) are metabolized more rapidly than the trans isomers to form up to seven dctinct S-oxidation products. The metabolic pathways for the cis- and trans-dithianes converge on one major dioxidized product, trans-2-(4-bromophenyl)-5-tert-butyl-1,3-dithiane cis-1,trans-3-dioxide