E. S. Reynolds, I. Lieberman, A. Kornberg
Mar 1, 1955
Citations
0
Influential Citations
31
Citations
Journal
Journal of Bacteriology
Abstract
Orotic acid (4-carboxyuracil) was shown to be a growth factor for one of the group C streptococci (Rogers, 1944), Lactobacillus casei (Chattaway, 1944), and Lactobacillus bulgarius, strain 09 (Wieland et al., 1950; Huff et al., 1950). Further studies with L. bulgaricus, strain 09 have revealed that ureidosuccinic acid partially replaces that orotic acid is also a nucleic acid pyrimidine precursor in mammalian tissues. Studies of orotic acid synthesis and breakdown with enzyme preparations from an anaerobic bacterium, Zymobacterium oroticum, have indicated the following pathway (Lieberman and Kornberg, 1953a; 1954, in preparation):