J. Booth, E. Boyland
Mar 1, 1970
Citations
0
Influential Citations
59
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract Nicotine-1′-oxide, prepared by the oxidation of (−)-nicotine with hydrogen peroxide, has been resolved into two optically active stereoisomers by fractional precipitation with ammonium reineckate. (−)-Nicotine is enzymically oxidized into both isomers of nicotine-1′-oxide in vitro. These enzyme systems are stereospecific since guinea-pig and rabbit liver form similar amounts of each stereoisomer white BALB/c mouse and hamster liver and guinea-pig lung synthesize chiefly laevo-rotatory nicotine-1′-oxide. Both stereoisomers of nicotine-1′-oxide were identified in the urine of cigarette smokers.