R. Mathur, R. Common
Dec 1, 1968
Citations
0
Influential Citations
5
Citations
Journal
Steroids
Abstract
Abstract A mixture of estradiol-17α-4-14C and estradiol-17α-17β-3H was injected into a laying hen. The ratios dpm 3H:dpm 14C of the urinary radioactive estradiol-17α and 17-epiestriol were practically identical whereas the corresponding ratio for the urinary radioactive 16, 17-epiestriol was considerably higher and approached the value for the injected estradiol-17α. These results show (a) that the 17-epiestriol and 16, 17-epiestriol were derived directly from the estradiol-17α and that estrone was not an intermediate product; and (b) that the formation of 16, 17-epiestriol was a relatively fast process. A general scheme for the pathways of in vivo derivation of the four estriol epimers in the hen is proposed on the basis of these and previous findings.