M. Tacker, W. McIsaac, P. Creaven
Oct 1, 1970
Citations
0
Influential Citations
22
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract Rats given tyramine-1-14C intraperitoneally excrete over 98 per cent of the administered radioactivity within 24 hr. Thirteen of the 15 urinary metabolites which account for almost 99 per cent of the radioactivity excreted in 24 hr were identified and estimated. p-Hydroxyphenylacetic acid, the major urinary metabolite, is excreted free (77 per cent of the urinary radioactivity), conjugated with glycine (10.5 per cent), with sulfate and glucuronic acid (4.2 per cent), and with both glycine and sulfate (0.7 per cent). About 2 per cent is excreted as free tyramine and tyramine-O-glucuronide. The neutral metabolites N-acetyltyramine and tyrosol are excreted conjugated with glucuronic acid or sulfate. Less than 0.2 per cent is excreted as free N-acetyltyramine. No free tyrosol was detected. A third neutral radioactive compound was tentatively identified as p-hydroxyphenylacetaldehyde (0.2 per cent). Two metabolites, which together constitute 1.1 per cent, were not identified.