C. Culvenor, J. Edgar, L. W. Smith
Feb 24, 1971
Citations
1
Influential Citations
18
Citations
Journal
Nature: New biology
Abstract
WHEN she reported the chronic hepatotoxicity of the alkaloids senkirkine and hydroxysenkirkine, which are esters of the aminoalcohol otonecine, Schoental1 suggested that 1,2-epoxides rather than pyrrolic derivatives2,3 are the active metabolites of hepatotoxic pyrrolizidine alkaloids. We have results which confirm the hepatotoxicity of otonecine esters but argue against the suggested involvement of 1,2-epoxides.