Wenchao Shu, Xuntong Zhang, Xiangyang Zhang
Oct 15, 2019
Citations
0
Influential Citations
25
Citations
Journal
The Journal of organic chemistry
Abstract
A molecular iodine mediated coupling cyclization reaction for the synthesis of 4-aryl-NH-1,2,3-triazoles has been developed from N-tosylhydrazones and sodium azide. This metal-free cascade [4+1] cyclization reaction could rapidly synthesize valuable compounds via a sequential C-N and N-N bond formation. Mechanistic studies demostrate that the nitrogen-atoms of the 1,2,3-triazoles are not entirely from sodium azide.