M. J. Cabrera-Afonso, Sara Cembellín, Adnane Halima-Salem
Oct 19, 2020
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Influential Citations
5
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Journal
Green Chemistry
Abstract
A sustainable synthesis of isothiazoles has been developed using an α-amino-oxy acid auxiliary and applying photoredox catalysis. This simple strategy features mild conditions, broad scope and wide functional group tolerance representing a new enviromentally friendly option to prepare these highly valuable heterocycles. Furthermore, the synthetic value of the method is highlighted by the preparation of a natural product derivative and the implementation of the reaction in a continuous flow setup.