Fang-Lin Tan, Ren‐Jie Song, Ming Hu
Jun 10, 2016
Citations
0
Influential Citations
49
Citations
Journal
Organic letters
Abstract
A new, metal-free oxidative 1,2-arylmethylation cascades of N-(arylsulfonyl)acrylamides for the assembly of 2,2-disubstituted-N-arylbutanamides containing an all-carbon quaternary center is presented. This reaction enables the one-step formation of two new C-C bonds through a sequence of methylation/1,4-aryl migration/desulfonylation using an organic peroxide as the methyl resource with a broad substrate scope and excellent functional group tolerance.