Carla M. Counceller, C. Eichman, B. C. Wray
Jan 30, 2008
Citations
0
Influential Citations
76
Citations
Quality indicators
Journal
Organic letters
Abstract
The synthesis of 1H-indazoles is achieved from o-aminobenzoximes by the selective activation of the oxime in the presence of the amino group. The reaction occurs with a variety of substituted o-aminobenzoximes using a slight excess of methanesulfonyl chloride and triethylamine at 0-23 degrees C and is amenable to scale-up. The synthesis of 1H-indazoles under these conditions is extremely mild compared with previous synthetic approaches and affords the desired compounds in good to excellent yields.