J. Lee, S. Kang, M. Kang
May 17, 1999
Citations
0
Influential Citations
39
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'-isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichia coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.