F. N. El-Dien, G. Mohamed, Noha M. Kamal El-Dien
2012
Citations
0
Influential Citations
1
Citations
Journal
International Journal of Chemical and Analytical Science
Abstract
Perindopril and meoxipril are ACE inhibitor and used in the treatment of hypertension and heart failure. [1] Perindopril is (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl] amino} propanoyl]-octahydro-1H-indole-2-carboxylic acid and meoxipril is (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4phenylbutan-2-yl] amino}propanoyl]-6,7-dimethoxy-1,2,3,4tetrahydroisoquinoline-3-carboxylic acid. Various methods are cited in the literature for the determination of perindopril such as amperometric biosensor [2-5], potentiometry [6], HPLC [7, 8] and spectrophotometry [9-15]. Meoxipril was determined by GC technique [16], carbon past electrode was used for the determination of meoxipril and it was enhanced by using sodium dodecyl sulphate [17]. It was also determined using PVC membrane electrode [18]. Simultaneous determination of meoxipril and hydrochlorothiazide in tablets by derivative spectrophotometric and high performance liquid chromatographic methods were also done [19]. An inspection of both the proposed method and the official ones for the cited drugs reveals that most of the official methods are cumbersome or involve the use of expensive equipments and reagents. Also, the proposed method is rapid and has very low detection limit which cannot be reached by most other methods. This paper reports simple, sensitive and accurate spectrophotometric method for the analysis of two antihypertensive agents namely perindopril and meoxipril in pure forms and pharmaceutical preparations.