Cheng De-jun
2004
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Journal
Progress in Pharmaceutical Sciences
Abstract
Objective: To study the preparation of ethyl 6,7-difluoro-1-methyl-4-oxo-1, 4-dihydro-[1,3] thiazeto [3,2-α] quinoline-3-carboxylate. Methods: The ethyl 6,7-difluoro-1-methyl-4-oxo-1,4-dihydro-[1, 3] thiazeto[3, 2-α]quinoline-3-carboxylate is prepared from ethyl 2-(ethylthio)-6, 7-difluoro-4-hydroxyquino- line-3-carboxylate through acetylation and cyclization. Results: This method is simple and convenient. The re- acting condition is moderate. Conclusion: This synthesis route is practical and easy to popularize in industry.