K. D. Praliev, N. Belikova, Zh. I. Isin
2004
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Journal
Pharmaceutical Chemistry Journal
Abstract
The reaction of CICOOEt with I in a boiling benzene solution leads to the formation of l-carbethoxy-4-piperidone (II) in 76% yield. Condensation of the latter with phenylmagnesium bromide gives l-carbethoxy-4-phenyl-4-piperidinol (III) in 68% yield. The desired end product IV is synthesized in 71.4% yield by treating III with an alcoholic solution of KOH. The overall yield of IV, based on I, is 36.5%.