F. J. Quijada, Javier González‐Sabín, F. Rebolledo
Sep 19, 2009
Citations
0
Influential Citations
9
Citations
Journal
Tetrahedron
Abstract
Abstract Optically active trans - N -Boc-cyclopentane- and cyclohexane-1,2-diamines ( 7 ) were prepared by a chemoenzymatic method from the corresponding (±)- trans - N , N -diallylcycloalkane-1,2-diamine. These mono-carbamates 7 (ee=99%) were used as the starting materials in the syntheses of different vicinal primary–tertiary diamines. Thus, by means of a simple three-step sequence involving a reductive-amination of an aromatic aldehyde with 7 , N-methylation and finally, cleavage of the Boc group, several trans - N -(arylmethyl)- N -methylcyclopentane- and cyclohexane-1,2-diamines were obtained in high yields.