Qu Xiao-ye
2006
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Journal
Chemistry World
Abstract
5-(3,4-Dichloro-phenyl)-dihydro-furan-2-one,an important intermediate of Sertraline hydrochloride which is a more effective drug for treatment of antidepressant,was prepared from 4-(3,4-dichloro-phenyl)-4-oxygenic-butyric-acid.A method to remove bubbles to get rid of impurity and to decrease the time of the reaction was found,i.e.to add 1 mL aqueous sodium hydroxide after adding sodium borohydride,to filtrate,intermediately to crystallize in an ice water bath.The reaction time was decreased from 16h to 4h,and the yield was 94%.