R. Khusnutdinov, N. A. Shchadneva, A. R. Bayguzina
Dec 3, 2004
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0
Influential Citations
4
Citations
Journal
Arkivoc
Abstract
Thiophenecarboxylic acid and its derivatives were synthesized by the reaction of thiophenes with the CCl4-CH3OH-catalyst system in total yields of 44-85%. The probable scheme of the reaction involves successive oxidation of methanol with tetrachloromethane to methyl hypochlorite and formaldehyde. Under the action of the latter, thiophene undergoes oxymethylation, giving rise to 2-oxymethylthiophene, which is oxidized with CH3OCl to 2- thiophenecarboxylic acid. In the presence of an excess of CH3OH, the latter is subjected to esterification. It was found that Fe(acac)3, VO(acac)2, and Mo(CO)6 are the catalysts of choice for this reaction.