Xu Dong-meib
2010
Citations
0
Influential Citations
0
Citations
Journal
Chemical Reagents
Abstract
(4-Trifluoromethylphenyl)acetic acid was prepared from 4-trifluoromethylaniline through the diazotization reaction,the Grignard reaction and the Wolff-Kishner-Huang reaction.The results indicated that at a molar ratio of n(Mg):n(p-bromobenzotrifluoride):n(diethyl oxalate)=1.2:1:1.5,a reaction temperature of 50~60 ℃,and a molar ratio of n(ethyl 4-trifluoromethylbenzoylformate):n(hydrazine hydrate)=1:1.2,the isolated product yield was 68.4%.The structure of the product and the intermediate were characterized by 1HNMR spectroscopy.