P. Jolimaître, C. André-Barrès, M. Malet-Martino
Nov 1, 1999
Citations
0
Influential Citations
11
Citations
Journal
Synlett
Abstract
: Bromo-tris(dimethylamino)-phosphonium-hexafluoro- phosphate (BROP) is a particularly suitable reagent for synthesising some 5-fluorouracil prodrugs in a one step reaction. Several acids, especially retinoic acid, were bound to the N 1 of 5-fluorouracil, with yields of about 50% after purification.