G. Bringmann, J. Geisler
Jul 15, 1990
Citations
0
Influential Citations
7
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract A simple, two-step-procedure for the synthesis of optically active ( S )-1-(2-fluorophenyl)- ethylamine ( 1 ) is described. Starting from commercially available 2-fluoro-acetophenone ( 2 ), imination with ( S )-1-phenyl-ethylamine ( 3 ), followed by stereoselective hydrogenation over Raney -nickel gives the secondary amine 5a. Subsequent regioselective hydrogenolytic cleavage of homogenous 5a yields enantiomerically pure 1