M. Al-Sheikh
Apr 1, 2011
Citations
0
Influential Citations
2
Citations
Journal
Journal of Saudi Chemical Society
Abstract
Abstract Ethyl 2-aryl-3-dimethylamino-acrylates 2a , b were prepared via the reaction of ethyl arylacetate with N , N -dimethylformamidedimethylacetal (DMFDMA) under microwave irradiation. Reaction of 2a , b with malononitrile afforded the corresponding substituted malononitrile derivatives 4a , b , which underwent intramolecular cyclization in boiling acetic acid, containing a catalytic amount of ammonium acetate, to give unexpected products 2-amino-6-hydroxy-5-(4-nitrophenyl)nicotinonitrile derivatives 6 . Whereas 2a reacted with o -phenylenediamines under microwave irradiation to yield diazepin-4-ol derivative 9 . On the other hand, reacting the enaminoesters 2a , b with urea and thiourea, as nitrogen nucleophiles, by heating under microwave yielded the pyrimidinone derivatives 12a – d .