Wei Fangfang
2008
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Journal
Chemical Research
Abstract
At first,2-bromoacetyl chloride was prepared by the reaction of bromoacetic acid and thionyl chloride.Secondly,tert-butyl 2-bromoacetate was synthesized by the reaction of 2-bromoacetyl chloride with tert-butanol at room temperature.The factors effecting the reaction were investigated and the optimum synthetic conditions were determined as follows:stoichiometric sodium tripolyphosphate was used as catalysts and tie-acid agents,chloroform as solvent,molar ratio of 2-bromoacetyl chloride to tert-butanol was 1:1.15,and the yield was 93.6 %.