Key Takeaway: This new method allows for the regioselective synthesis of thioethers from phenyl N-sulfonamide, with no catalyst or additive needed, avoiding contamination from transition metal catalysts.
Abstract
A operationally simple, one-pot for regioselective synthesis of thioether route
directly from phenyl N-sulfonamide by using inexpensive, easily handled trimethylsilyl iodide
as reducing agent, acetonitrile as the solvent is described. Further no catalyst or additive are
required, which avoids contamination from the transition metal catalysts in the products.