R. Testa, R. Latini
2010
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Influential Citations
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Quality indicators
Journal
European Journal of Drug Metabolism and Pharmacokinetics
Abstract
SummaryThe urinary excretion data after I.M. administration of water soluble lysine salt of Alclofenac were analysed by the techniques suggested by Niebergall, Wagner, Martin and Cuinmings. All methods used give similar estimates of both DU∞ and Kel with exception of the “Sigma minus” method when DU∞ obtained by “Rate Method” was utilized. Niebergall’s method is preferred on the basis that it provides an accurate estimation of both DU∞ and Kel. These parameters, evaluated after administration of Alclofenac-lysinate, resulted in agreement with previously reported data obtained after administration of different pharmaceuticals of acidic drug.