A. Sausln'sh, B. Chekavlchus, G. Duburs
Jul 1, 1995
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Journal
Chemistry of Heterocyclic Compounds
Abstract
The most suitable method for the synthesis of 4-pyrazolyl- or 4-pyridyl-5-oxo-1, 4, 5, 7-tetrahydrofuro[3, 4b]pyridines uses 4-chloro- or 4-acetoxyacetoacetic esters in various versions of the Hantsch synthesis with closure of a lactone ring during the reaction. Some of the intermediate products (2-chloromethyl- and 2acetoxymethyl-1,4-dihydropyridines) were isolated. Cyclization with the formation of lactones does not occur in N-substituted 1, 4-dihydropyridines.