Qing‐Yun Chen, D. Su, Jian-Xing Duan
Sep 1, 1991
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Journal
Journal of Fluorine Chemistry
Abstract
Abstract Treatment of methyl chlorodifluoroacetate, ClCF 2 CO 2 Me(1), with organic halides (2) in the presence of potassium fluoride and CuI in DMF at 100–120°C for 6–7 hrs gave the corresponding trifluoromethyl derivatives(3) in moderate to high yields with simultaneous elimination of CO 2 and methylhalide. The detail of conditions and mechanism will be presented.