Ajit K. Ghosh, D. Farquhar
Dec 22, 1997
Citations
0
Influential Citations
10
Citations
Journal
Tetrahedron Letters
Abstract
Abstract 4-[Methyl (β-D-glucopyranosyl)uronate]benzyl N,N,N′,N′-tetrakis(2-chloroethyl) phosphorodiamidate, 3 , was synthesized as a neutral prodrug of N,N,N′,N′-tetrakis(2-chloroethyl) phosphorodiamidate mustard, 2c . In the presence of carboxylate esterase and β-D-glucuronidase, 3 was converted to 2c and 4-hydroxybenzyl alcohol, 7 .